A man is taken to a small clinic in Guam with mysterious bites on him. This sparks a search for what could have caused such wounds. A group of men and women fly to the island he lived on to investigate the situation. Due to technical problems, their small plane crashes and they are stranded on the island. After some time, they come to find the man's village is empty and that strange new breeds of killer arachnids have appeared all about the forest.