Will Graham is a special consultant with the FBI. He has a special gift whereby he can empathize with any individual and put himself in their shoes. This means he gets to help solve vicious murders, especially those involving serial killers, as he can profile the murderer - their method, motives and personality profile. For a particular case, the FBI also seek the help of Dr. Hannibal Lecter, a highly-respected psychiatrist. Will and Hannibal hit it off, and Will becomes a patient of Hannibal. Little does he know or suspect that Hannibal might be the most wanted serial killer in the US.